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M9471074.TXT
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1994-08-09
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Document 1074
DOCN M9471074
TI Dietary carotenoids, cigarette smoking and Kaposi's sarcoma in the San
Francisco Men's Health Study.
DT 9409
AU Duncan DM; Univ. of California, Berkeley
SO Diss Abstr Int [B]; 53(9):4596 1993. Unique Identifier : AIDSLINE
ICDB/94690808
AB This study utilized data from the San Francisco Men's Health Study
(SFMHS) to explore the relationship between dietary intake and
subsequent development of Kaposi's sarcoma (KS) in a cohort of men at
high risk for acquired immunodeficiency syndrome (AIDS). The SFMHS is a
prospective study observing the natural history of AIDS conducted on a
probability sample of over 1000 men aged 25 to 54 yr, who resided in the
census tracts of San Francisco with the highest cumulative incidence of
AIDS through December 1983. In 1984, dietary information was obtained
during the first cycle of data collection, using the Health Habits and
History Questionnaire (HHHQ), a food frequency questionnaire developed
by the National Cancer Institute (NCI). Univariate analysis revealed a
statistically significant relationship between energy-adjusted tertiles
of carotenoid intake and KS development, with the lowest tertile of
intake increasing the risk of KS, relative risk (RR) = 2.91. After
adjusting for covariates that remained significant in multiple logistic
regression analysis (college education, cigarette smoking and poor
health at study baseline), the risk of KS appeared to be highly
inversely associated with carotenoid intake (odds ratio for lowest
tertile = 4.06, 95% confidence interval (Cl) 1.39-11.89, odds ratio for
middle tertile = 3.01, 95% Cl 1.03-8.85, test for trend p-value = 0.02,
and Likelihood Ratio Test chi square = 7.80, p-value = 0.020). No other
nutrient was significantly associated with KS development in
multivariate analysis. Stratification by smoking status showed the
relationship between a low carotenoid intake and an increased risk of KS
to be in smokers only (for smokers, odds ratio for lowest tertile =
7.67, 95% Cl 1.68-35.09, odds ratio for middle tertile = 3.25, 95% Cl
0.66-15.88, test for trend p-value = 0.05, and Likelihood Ratio Test chi
square = 8.48, p-value = 0.014). (Full text available from University
Microfilms International, Ann Arbor, MI, as Order No. AAD92-28635.)
DE Acquired Immunodeficiency Syndrome/COMPLICATIONS/EPIDEMIOLOGY Adult
Carotenoids/*THERAPEUTIC USE Cohort Studies *Diet Human Male Middle
Age Odds Ratio Questionnaires Regression Analysis San
Francisco/EPIDEMIOLOGY Sarcoma, Kaposi's/DIET THERAPY/*ETIOLOGY
*Smoking THESIS
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).